Evolutionary Optimization of Protein Folding
نویسندگان
چکیده
منابع مشابه
Evolutionary Optimization of Protein Folding
Nature has shaped the make up of proteins since their appearance, [Formula: see text]3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be elucidated. Here we explore if protein evolution affects folding speed. We estimated folding times for the present-day catalog of protein domains directly from thei...
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Our work suggests that the forces that govern protein folding exert a profound effect on how genotypes are translated into phenotypes and that this in turn has strong effects on evolutionary processes. Molecular chaperones, also known as "heat-shock proteins" (Hsps), promote the correct folding and maturation of many other proteins in the cell. Hsp90 is an abundant and highly specialized chaper...
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To my mentors iii ACKNOWLEDGEMENTS First, I would like to express my sincere appreciation to my advisor, Dr. Joel Sokol for his invaluable guidance, support, inspiration, understanding, and friendship throughout the entire period of my research. Dr. Emilie Danna for their willingness to serve on my dissertation committee and for their valuable comments and suggestions. I also thank Dr. Emilie D...
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The sequence and structural conservation of folding transition states have been predicted on theoretical grounds. Using homologous sequence alignments of proteins previously characterized via coupled mutagenesis/kinetics studies, we tested these predictions experimentally. Only one of the six appropriately characterized proteins exhibits a statistically significant correlation between residues'...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002861